Acthar binds to the 5 identified MCRs1-3*
Acthar binds to the 5 MCRs, potentially providing a different way to impact various immune cells1-3*
*While the exact mechanism of action of Acthar is unknown, further investigation is being conducted. This information is based on nonclinical data and the relationship to clinical benefit is unknown.
MCRs are found on a range of immune cells as well as on certain ocular cells.2
MCRs are expressed on immune cells throughout the body.2-4
MCRs are expressed in the eye on retinal pigment epithelial cells.5-6
Melanocortin peptides bind to and are believed to activate MCRs throughout the body3*
Acthar is indicated for severe acute and chronic allergic and inflammatory processes involving the eye and its adnexa such as: keratitis, iritis, iridocyclitis, diffuse posterior uveitis and choroiditis, optic neuritis, chorioretinitis, anterior segment inflammation.
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1. Injecting Acthar: Introduction
2. Getting Started With Acthar01:57
3. Preparing the Dose Ordered for You
4. Preparing to Inject
5. Drawing Up Acthar Into the Syringe
6. Choosing Where to Inject
7. Injecting Subcutaneously
8. Disposing of Used Materials
9. Storing Acthar
10. Patient Support Services
11. Important Safety Information
2. Getting Started With Acthar
3. Preparing the Dose Ordered for You0:59
4. Preparing to Inject00:49
7. Injecting Intramuscularly
Potential Mechanism of Action Video
Hear From Dennis: An Acthar Patient
SC Injection Training Video
IM Injection Training Video